Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 19/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473615 | 0.91 | NPC1L1 (0.50) | NPC1L1 | |
| SCHEMBL5950667 | 0.89 | NPC1L1 (0.47) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL5779643 | 0.85 | OPRL1 (0.43) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL6474755 | 0.84 | ENPP2 (0.44) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL6473614 | 0.84 | OPRL1 (0.42) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL6474705 | 0.84 | OPRL1 (0.47) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL5800911 | 0.83 | NPC1L1 (0.49) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL6475235 | 0.83 | OPRL1 (0.41) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL5782629 | 0.83 | OPRM1 (0.46) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL6619869 | 0.83 | NPC1L1 (0.48) | NPC1L1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919349-B2 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES, INC. (JP) | 2005-07-19 | — | — | US | disclosed |
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES INC. (JP) | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | VCAM1, ICAM1, SELL | NPC1L1 2533/4885OPRM1 2044/4885OPRK1 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.