Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 18/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802422 | 0.91 | NPC1L1 (0.49) | NPC1L1 | |
| SCHEMBL5950765 | 0.88 | ENPP2 (0.50) | NPC1L1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5802411 | 0.84 | ENPP2 (0.46) | NPC1L1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5799989 | 0.83 | ENPP2 (0.44) | NPC1L1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5799004 | 0.83 | ENPP2 (0.50) | NPC1L1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6481297 | 0.83 | NPC1L1 (0.50) | NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL5802331 | 0.83 | BDKRB2 (0.47) | NPC1L1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5799770 | 0.82 | OPRM1 (0.41) | NPC1L1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5800244 | 0.81 | CCR5 (0.52) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5799178 | 0.81 | ENPP2 (0.43) | NPC1L1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329451-B1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES (JP) | 2006-08-23 | — | — | EP | disclosed |
| US-6919349-B2 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES, INC. (JP) | 2005-07-19 | — | — | US | disclosed |
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES INC. (JP) | 2004-05-06 | — | — | US | disclosed |
| EP-1329451-A1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2003-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | VCAM1, ICAM1, SELL | NPC1L1 2533/4885OPRM1 2044/4885OPRD1 1982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.