Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049812 | 0.80 | PDE4A (0.39) | PDE4APDE4CPDE4DCA2CA1 | |
| SCHEMBL5748165 | 0.78 | CCR1 (0.44) | PDE4APDE4CPDE4DCA2CA1 | |
| SCHEMBL31090281 | 0.78 | PDE4A (0.45) | PDE4APDE4CPDE4DCA2CA1 | |
| SCHEMBL22116245 | 0.76 | PDE4A (0.53) | PDE4APDE4CPDE4D | |
| SCHEMBL11945522 | 0.75 | CA1 (0.40) | PDE4APDE4CPDE4DESR2CXCR2 | |
| SCHEMBL538501 | 0.74 | PDE4A (0.44) | PDE4APDE4CPDE4DCA2CA1 | |
| SCHEMBL24998589 | 0.73 | TRPV1 (0.34) | — | |
| SCHEMBL28544908 | 0.73 | ESR2 (0.47) | ESR2CA2CA1ALDH1A1ESR1 | |
| SCHEMBL23674532 | 0.72 | CA1 (0.39) | PDE4APDE4CPDE4DCXCR2CA2 | |
| SCHEMBL2462671 | 0.72 | LNPEP (0.41) | CA2CA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919470-B2 | Aryl and heteroaryl sulfonates | BAYER AKTIENGESELLSCHAFT (DE) | 2005-07-19 | — | — | US | disclosed |
| US-6900209-B2 | Nitrogen substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives for enhancing cognition | MERCK SHARP & DOHME LTD. | 2005-05-31 | — | — | US | disclosed |
| US-20040043982-A1 | Nitrogen substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2004-03-04 | — | — | US | disclosed |
| US-20030232802-A1 | Aryl and heteroaryl sulfonates | HEIL MARKUS (DE) | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043982-A1 | Nitrogen substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives for enhancing cognition | PSEN1, BDNF, H1-5 | PDE4A 1882/4885PDE4C 2688/4885PDE4D 2077/4885 |
| US-20030232802-A1 | Aryl and heteroaryl sulfonates | ARSA, SNCA, ATXN2 | PDE4A 3784/4885PDE4C 3634/4885PDE4D 3839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.