Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | NPFFR1 | Q9GZQ6 | 3/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726909 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1304439 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL648157 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL111119 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL113975 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9351222 | 0.83 | NPFFR1 (0.58) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9351215 | 0.83 | NPFFR1 (0.58) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2166114 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1937076 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1937074 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170304299-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LTD (IN) | 2017-10-26 | — | — | US | disclosed |
| US-9737534-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2017-08-22 | — | — | US | disclosed |
| US-20160022673-A1 | OXAZOLE AND ISOXAZOLE CRAC MODULATORS | LUPIN LIMITED (IN) | 2016-01-28 | — | — | US | disclosed |
| US-9169242-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2015-10-27 | — | — | US | disclosed |
| US-20130225600-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2013-08-29 | — | — | US | disclosed |
| US-8053452-B2 | Substituted isoxazoline or enone oxime compound, and pest control agent | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20100144808-A1 | SUBSTITUTED ISOXAZOLINE OR ENONE OXIME COMPOUND, AND PEST CONTROL AGENT | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-06-10 | — | — | US | disclosed |
| EP-2172448-A1 | SUBSTITUTED ISOXAZOLINE OR ENONE OXIME COMPOUND, AND PEST CONTROL AGENT | Nissan Chemical Industries, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022673-A1 | OXAZOLE AND ISOXAZOLE CRAC MODULATORS | RYR2, RYR1, GABRR1 | SMN1; SMN2 1083/4885RAB9A 3236/4885ALDH1A1 580/4885 |
| US-20170304299-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | RYR2, ADRA2C, RYR1 | SMN1; SMN2 856/4885RAB9A 3278/4885ALDH1A1 607/4885 |
| US-20130225600-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | RYR2, ADRA2C, RYR1 | SMN1; SMN2 856/4885RAB9A 3278/4885ALDH1A1 607/4885 |
| US-20100144808-A1 | SUBSTITUTED ISOXAZOLINE OR ENONE OXIME COMPOUND, AND PEST CONTROL AGENT | MLYCD, MT-CO2, TRHDE | SMN1; SMN2 1380/4885RAB9A 1242/4885ALDH1A1 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.