Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 5/20 | 0.64 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.64 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.64 |
| ▸ | F10 | P00742 | 2/20 | 0.64 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 6/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.53 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | MASP2 | O00187 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | C1S | P09871 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717268 | 0.80 | PRSS1 (0.70) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL537030 | 0.79 | LMNA (0.77) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL2800579 | 0.78 | PRSS1 (0.67) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL49594 | 0.78 | LOXL2 (1.00) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL1587086 | 0.78 | PRSS1 (1.00) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL1468317 | 0.77 | LMNA (0.59) | PRSS1PRSS3PRSS2F10LOXL2 | |
| Hydrochloric Acid SCHEMBL322008 | 0.76 | LOXL2 (0.95) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL1587085 | 0.76 | PRSS1 (0.64) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL1696572 | 0.76 | PRSS1 (0.64) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL2537663 | 0.76 | PLA2G10 (0.57) | ALDH1A1CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908919-B2 | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-06-21 | — | — | US | disclosed |