Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CETP | P11597 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129664 | 0.85 | MAPT (0.45) | CYP1A2CYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL6476093 | 0.83 | CETP (0.59) | CETP | |
| SCHEMBL993541 | 0.82 | CETP (0.57) | CETP | |
| SCHEMBL7123071 | 0.79 | ALPL (0.36) | CYP1A2CYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL6475752 | 0.77 | CETP (0.47) | CETPGCGR | |
| SCHEMBL6040442 | 0.76 | CETP (0.67) | CETP | |
| SCHEMBL14491048 | 0.74 | CETP (0.58) | CETP | |
| SCHEMBL7979351 | 0.73 | LMNA (0.80) | CYP1A2CYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL6476598 | 0.73 | CETP (0.70) | CETP | |
| SCHEMBL6475334 | 0.73 | CETP (0.55) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897317-B2 | 4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein | BAYER AKTIENGESELLSCHAFT (DE) | 2005-05-24 | — | — | US | disclosed |
| US-20030232990-A1 | 4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein | BAYER AKTIENGESELLSCHAFT | 2003-12-18 | — | — | US | disclosed |
| US-6562976-B2 | Such as methyl-2-cyclopentyl-4-(4-fluorophenyl)-5-oxo-7,7-dimethyl-1,4,5,6,7,8 -hexahydroquinoline-3-carboxylate for treatment of arteriosclerosis and dyslipidaemias; condensation | BAYER AKTIENGESELLSCHAFT (DE) | 2003-05-13 | — | — | US | disclosed |
| US-20020165252-A1 | 4-phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein | BAYER AKTIENGESELLSCHAFT | 2002-11-07 | — | — | US | disclosed |
| US-20020042515-A1 | Tetrahydroquinolines | SCHMIDT GUNTER (DE) | 2002-04-11 | — | — | US | disclosed |
| US-6291477-B1 | Tetrahydroquinolines, processes for their preparation, pharmaceutical compositions containing them, and their use to prevent or treat hyperlipoproteinaemia | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042515-A1 | Tetrahydroquinolines | HMGCR, DHCR7, LIPA | CYP1A2 238/4885CYP2C9 644/4885CYP2C19 567/4885 |
| US-20020165252-A1 | 4-phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein | CETP, LCAT, ACAT2 | CYP1A2 1146/4885CYP2C9 1644/4885CYP2C19 1597/4885 |
| US-20030232990-A1 | 4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein | CETP, LCAT, ACAT2 | CYP1A2 1227/4885CYP2C9 1773/4885CYP2C19 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.