Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 11/20 | 0.54 |
| ▸ | IMPDH1 | P20839 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27542606 | 0.85 | IMPDH2 (0.64) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6486382 | 0.84 | IMPDH2 (0.70) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6499362 | 0.81 | IMPDH2 (0.59) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| Trifluoroacetic Acid SCHEMBL27561206 | 0.80 | IMPDH2 (0.53) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6493937 | 0.77 | IMPDH2 (0.52) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6485457 | 0.76 | IMPDH2 (0.56) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL27561207 | 0.75 | IMPDH2 (0.67) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL27571122 | 0.74 | IMPDH2 (0.71) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL7552277 | 0.71 | IMPDH2 (0.60) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL14267693 | 0.71 | IMPDH2 (1.00) | IMPDH2IMPDH1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |