Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.49 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485457 | 0.83 | IMPDH2 (0.56) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL6499362 | 0.81 | IMPDH2 (0.59) | IMPDH2NPC1RAB9AKDM4EPKM | |
| Trifluoroacetic Acid SCHEMBL27561206 | 0.77 | IMPDH2 (0.53) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL6486557 | 0.77 | IMPDH2 (0.54) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL14027190 | 0.73 | KMT2A (0.76) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL27542606 | 0.73 | IMPDH2 (0.64) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL6484655 | 0.73 | IMPDH2 (0.64) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL6500618 | 0.72 | IMPDH2 (0.72) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL7552277 | 0.71 | IMPDH2 (0.60) | IMPDH2NPC1RAB9AKDM4EPKM | |
| SCHEMBL12749611 | 0.71 | NPC1 (0.65) | IMPDH2NPC1RAB9AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |