Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 8/20 | 0.59 |
| ▸ | IMPDH1 | P20839 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7552277 | 0.89 | IMPDH2 (0.60) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6496013 | 0.83 | IMPDH2 (0.74) | IMPDH2IMPDH1AAK1 | |
| Trifluoroacetic Acid SCHEMBL27561206 | 0.81 | IMPDH2 (0.53) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6486557 | 0.81 | IMPDH2 (0.54) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL12344525 | 0.81 | IMPDH2 (0.56) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6493937 | 0.81 | IMPDH2 (0.52) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL7543123 | 0.80 | NPC1 (0.56) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6485457 | 0.80 | IMPDH2 (0.56) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL15110902 | 0.80 | VHL (0.54) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL12749611 | 0.79 | NPC1 (0.65) | IMPDH2NPC1RAB9AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |
| US-20020052513-A1 | Oxamide IMPDH inhibitors | HOFFMANN-LA ROCHE INC. | 2002-05-02 | — | — | US | disclosed |
| EP-1127883-A2 | Oxamides as IMPDH inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052513-A1 | Oxamide IMPDH inhibitors | IMPDH1, IMPDH2, IMPA1 | IMPDH2 2/4885IMPDH1 1/4885NPC1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.