Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 15/20 | 0.56 |
| ▸ | IMPDH1 | P20839 | 10/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484655 | 0.91 | IMPDH2 (0.64) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6485360 | 0.86 | IMPDH2 (0.68) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6493937 | 0.83 | IMPDH2 (0.52) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6494993 | 0.83 | IMPDH2 (0.56) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6499362 | 0.80 | IMPDH2 (0.59) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| Trifluoroacetic Acid SCHEMBL27561206 | 0.78 | IMPDH2 (0.53) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL27542606 | 0.78 | IMPDH2 (0.64) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6486557 | 0.76 | IMPDH2 (0.54) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6497151 | 0.73 | IMPDH2 (1.00) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6500618 | 0.73 | IMPDH2 (0.72) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |