Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27213590 | 0.86 | GPR119 (0.48) | GPR119ACKR3CHRM2CHRM4CHRM1 | |
| SCHEMBL5232122 | 0.79 | GPR119 (0.41) | GPR119ACKR3HRH1TLR8CHRM2 | |
| SCHEMBL5228089 | 0.77 | SMN1; SMN2 (0.53) | ACKR3SIGMAR1HRH1TLR8CHRM2 | |
| SCHEMBL24963003 | 0.76 | GPR119 (0.53) | GPR119 | |
| SCHEMBL6894349 | 0.75 | GPR119 (0.43) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7245807 | 0.74 | HRH2 (0.71) | GPR119HRH1HRH2HRH3EPHX2 | |
| SCHEMBL7971782 | 0.74 | SIGMAR1 (0.69) | ACKR3SIGMAR1HRH1HTR1ADRD4 | |
| SCHEMBL20873847 | 0.74 | USP2 (0.53) | ACKR3SIGMAR1TLR8CHRM2CHRM4 | |
| SCHEMBL11351472 | 0.73 | MAPT (0.44) | GPR119ACKR3TLR8CHRM2CHRM4 | |
| SCHEMBL9743736 | 0.73 | ACKR3 (0.48) | GPR119ACKR3SIGMAR1TLR8CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906072-B1 | Piperazine compound and pharmaceutical composition containing the compound | EISAI CO., LTD. (JP) | 2005-06-14 | — | — | US | disclosed |