SCHEMBL6487402

SCHEMBL6487402

Cc1ccc(-c2ccc(Cl)cc2)c(C(=O)Nc2ccc(NCCc3cccc(N)n3)nc2)c1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GCGR P47871 3/20 0.41
SCN2A Q99250 1/20 0.39
SCN10A Q9Y5Y9 1/20 0.39
CTNNB1 P35222 1/20 0.39
TCF7L2 Q9NQB0 1/20 0.39
F10 P00742 8/20 0.38
MAP4K4 O95819 1/20 0.37
ALDH1A1 P00352 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
PIK3CA P42336 1/20 0.36
MTOR P42345 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6490273 0.91 GCGR (0.43) GCGRSCN2ASCN10ACTNNB1TCF7L2
SCHEMBL6489350 0.90 APOB (0.43)
SCHEMBL6501443 0.85 PIK3CA (0.40) GCGRSCN2ASCN10AF10SMN1; SMN2
SCHEMBL6492232 0.85 CYP3A4 (0.41) ALDH1A1
SCHEMBL6487481 0.84 F10 (0.43) CTNNB1TCF7L2F10SMN1; SMN2
SCHEMBL6489781 0.82 L3MBTL1 (0.47) SMN1; SMN2
SCHEMBL6500632 0.82 ITGB1 (0.44) GCGRSCN2ASCN10AF10
SCHEMBL6489345 0.81 GCGR (0.51) GCGRCTNNB1TCF7L2SMN1; SMN2
SCHEMBL6493011 0.80 MTTP (0.48)
SCHEMBL6497868 0.80 PIK3CA (0.42) SMN1; SMN2PIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors DAISO CO., LTD. (JP) 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors APOB, APOL1, CTRB2 GCGR 1784/4885SCN2A 614/4885SCN10A 1840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.