Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24353670 | 0.84 | SCN4A (0.47) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL18496496 | 0.82 | IDO1 (0.55) | ALDH1A1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL10712718 | 0.82 | CNR2 (0.56) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL6487591 | 0.80 | PDE1B (0.43) | ALDH1A1NPSR1L3MBTL1LPAR1CNR2 | |
| SCHEMBL10709535 | 0.78 | NPSR1 (0.44) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL10798581 | 0.77 | SCN4A (0.42) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL9231158 | 0.77 | LMNA (0.50) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL9228033 | 0.76 | NPSR1 (0.54) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL23748311 | 0.76 | GAA (0.51) | ALDH1A1NPSR1L3MBTL1LMNAMAPT | |
| SCHEMBL9228936 | 0.75 | ALDH1A1 (0.50) | ALDH1A1NPSR1L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933322-B2 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | WYETH (US) | 2005-08-23 | — | — | US | disclosed |
| US-20030216442-A1 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | WYETH | 2003-11-20 | — | — | US | disclosed |
| EP-0149077-B1 | (3-ARYL-2,3-DIHYDROBENZOFURAN-3-YL)ALKYLAMINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4602035-A | Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0149077-A1 | (3-Aryl-2,3-dihydrobenzofuran-3-yl)alkylamines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216442-A1 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | INSR, GPR119, SLC5A1 | ALDH1A1 648/4885NPSR1 714/4885L3MBTL1 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.