Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633600 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1MAPTPIM1GFER | |
| SCHEMBL6029052 | 0.75 | DHODH (0.49) | KDM4EALDH1A1GAAPDPK1PLK4 | |
| SCHEMBL6028084 | 0.75 | DHODH (0.59) | KDM4EALDH1A1GAAPDPK1PLK4 | |
| SCHEMBL6029606 | 0.73 | DHODH (0.78) | KDM4EALDH1A1GAAPDPK1PLK4 | |
| SCHEMBL31423274 | 0.73 | PDPK1 (0.53) | KDM4EALDH1A1GAAPDPK1PLK4 | |
| SCHEMBL19857562 | 0.73 | PDPK1 (0.53) | KDM4EALDH1A1GAAPDPK1PLK4 | |
| SCHEMBL9474474 | 0.73 | DYRK1A (0.49) | CHEK1FLT3CASP7 | |
| SCHEMBL29696398 | 0.73 | PDPK1 (0.53) | KDM4EALDH1A1GAAPDPK1PLK4 | |
| SCHEMBL8821216 | 0.72 | BCAT2 (0.50) | KDM4EALDH1A1GAAPDPK1MAPT | |
| SCHEMBL6028357 | 0.72 | DHODH (0.59) | PDPK1TDP1PLK4CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187172-A1 | Combination of a Cox-2 inhibitor and a DNA topoisomerase I inhibitor for treatment of neoplasia | PFIZER INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187172-A1 | Combination of a Cox-2 inhibitor and a DNA topoisomerase I inhibitor for treatment of neoplasia | TOP2A, TOP2B, TOP1 | KDM4E 3266/4885ALDH1A1 1202/4885GAA 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.