Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | GFER | P55789 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 2/20 | 0.58 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487987 | 0.87 | KDM4E (0.51) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL16474101 | 0.76 | DHODH (0.94) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL6691511 | 0.75 | KDM4E (1.00) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL9474474 | 0.74 | DYRK1A (0.49) | CDC25BCYP1A2 | |
| SCHEMBL505036 | 0.74 | DHODH (1.00) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL11035155 | 0.74 | HSD17B10 (0.62) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL7648523 | 0.73 | KDM5B (0.60) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL8633602 | 0.73 | KDM4E (0.50) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL29415464 | 0.72 | DHODH (0.58) | KDM4EGFERMAPTPIM1TDP1 | |
| SCHEMBL2808417 | 0.72 | DHODH (0.58) | KDM4EGFERMAPTPIM1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601191-B1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5371225-A | Immunosuppressants | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| EP-0601191-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1994-06-15 | — | — | EP | disclosed |