SCHEMBL6488909

SCHEMBL6488909

CCOC(=O)CCN(C(=O)OC(C)(C)C)C1CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.35
ALDH1A1 P00352 5/20 0.35
TSHR P16473 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP1A2 P05177 2/20 0.34
HDAC6 Q9UBN7 2/20 0.34
POLB P06746 2/20 0.34
LMNA P02545 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
CYP2C19 P33261 2/20 0.34
CYP2D6 P10635 1/20 0.34
HIF1A Q16665 1/20 0.34
SMYD3 Q9H7B4 1/20 0.33
USP2 O75604 1/20 0.33
ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6501399 0.96 NFKB1 (0.39) NFKB1NFKB2RELASMN1; SMN2ALDH1A1
SCHEMBL6495211 0.94 ALDH1A1 (0.39) NFKB1NFKB2RELASMN1; SMN2ALDH1A1
SCHEMBL6499787 0.93 ALDH1A1 (0.41) NFKB1NFKB2RELASMN1; SMN2ALDH1A1
SCHEMBL15297743 0.87 GPR119 (0.43) SMN1; SMN2ALDH1A1TSHRMEN1KMT2A
SCHEMBL1720428 0.85 NFKB1 (0.41) NFKB1NFKB2RELAALDH1A1TSHR
SCHEMBL15297554 0.84 NR1H2 (0.40) NFKB1NFKB2RELASMN1; SMN2ALDH1A1
SCHEMBL16921539 0.82 HDAC6 (0.36) NFKB1NFKB2RELAALDH1A1HDAC6
SCHEMBL6498594 0.81 CA14 (0.34) HDAC6HDAC1HDAC2L3MBTL1
SCHEMBL15370101 0.81 NFKB1 (0.40) NFKB1NFKB2RELASMN1; SMN2ALDH1A1
SCHEMBL20408343 0.80 ALDH1A1 (0.37) NFKB1NFKB2RELAALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6903107-B1 Serine protease inhibitor AKZO NOBEL N.V. (NL) 2005-06-07 US disclosed
US-5763604-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1998-06-09 US disclosed
US-5677448-A CHEMICAL INTERMEDIATES FOR MAKING ANTAGONIST OF THROMBIN, TREATING THROMBOSIS, STROKE, INFLAMMATION, ARTERIOSCLEROSIS, CARDIOVASCULAR DISORDERS HOFFMANN-LA ROCHE INC. (US) 1997-10-14 US disclosed
US-5578594-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-11-26 US disclosed
US-5405854-A Anticoagulants HOFFMANN-LA ROCHE INC. (US) 1995-04-11 US disclosed
CN-1076690-A SULFONAMIDOCARBOXAMIDES HOFFMANN LA ROCHE (CH) 1993-09-29 CN disclosed