Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865768 | 0.86 | ALDH1A1 (0.65) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL13485335 | 0.80 | MAPT (0.57) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL11556894 | 0.79 | ALDH1A1 (0.52) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL11556898 | 0.79 | ALDH1A1 (0.52) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8543873 | 0.78 | EGFR (0.64) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL14970320 | 0.78 | MAPT (0.62) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL17466928 | 0.77 | ALDH1A1 (0.54) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL30457529 | 0.77 | KMT2A (0.56) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL30729660 | 0.77 | MAPT (0.54) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL3368556 | 0.77 | KMT2A (0.54) | MAPTKMT2AALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232453-B | 2- ((benzotriazolyl) (3-bromophenyl) methylene) malononitrile and preparation method thereof | 天津师范大学 | 2021-07-20 | — | — | CN | claimed |
| CN-109232453-A | 2- ((benzotriazole base) (3- bromophenyl) methylene) malononitrile and preparation method thereof | 天津师范大学 | 2019-01-18 | — | — | CN | claimed |
| EP-3553097-B1 | COPOLYMER AND OPTICAL FILM USING SAME | TOSOH CORP (JP) | 2022-05-04 | — | — | EP | disclosed |
| US-11225540-B2 | Copolymer and optical film using same | TOSOH CORPORATION (JP) | 2022-01-18 | — | — | US | disclosed |
| CN-110092734-B | Tandem synthesis method of 2- (phenylmethylene) malononitrile or derivatives thereof | 华侨大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-109232453-B | 2- ((benzotriazolyl) (3-bromophenyl) methylene) malononitrile and preparation method thereof | 天津师范大学 | 2021-07-20 | — | — | CN | disclosed |
| CN-109232453-B | 2- ((benzotriazolyl) (3-bromophenyl) methylene) malononitrile and preparation method thereof | 天津师范大学 | 2021-07-20 | — | — | CN | disclosed |
| US-20200095358-A1 | COPOLYMER AND OPTICAL FILM USING SAME | TOSOH CORPORATION (JP) | 2020-03-26 | — | — | US | disclosed |
| CN-110818592-A | Tandem reaction synthesis method of 2- (phenylmethylene) malononitrile or derivatives thereof | 华侨大学 | 2020-02-21 | — | — | CN | disclosed |
| EP-3553097-A1 | COPOLYMER AND OPTICAL FILM USING SAME | Tosoh Corporation (JP) | 2019-10-16 | — | — | EP | disclosed |
| CN-109232453-A | 2- ((benzotriazole base) (3- bromophenyl) methylene) malononitrile and preparation method thereof | 天津师范大学 | 2019-01-18 | — | — | CN | disclosed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |
| EP-0989986-A1 | 5,7-DISUBSTITUTED 4-AMINOPYRIDO 2,3-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS | Abbott Laboratories (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1999050254-A1 | QUINOXALINONES AS SERINE PROTEASE INHIBITORS SUCH AS FACTOR XA AND THROMBIN | WARNER-LAMBERT COMPANY (US) | 1999-10-07 | — | — | WO | disclosed |
| WO-1999050257-A1 | BENZOXAZINONES/BENZOTHIAZINONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-10-07 | — | — | WO | disclosed |
| WO-1998046605-A1 | 5,7-DISUBSTITUTED 4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1998-10-22 | — | — | WO | disclosed |
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |