Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PIEZO1 | Q92508 | 5/20 | 0.53 |
| ▸ | GRK6 | P43250 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14027202 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAALDH1A1POLBPLA2G1B | |
| SCHEMBL6490578 | 0.69 | PIEZO1 (1.00) | SMN1; SMN2LMNAPIEZO1NPC1ALDH1A1 | |
| SCHEMBL17280119 | 0.65 | SMN1; SMN2 (0.59) | SMN1; SMN2GRK6NPC1ALDH1A1MAPT | |
| SCHEMBL17279720 | 0.65 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNANPC1L3MBTL1RAB9A | |
| SCHEMBL11320053 | 0.64 | SMN1; SMN2 (0.53) | SMN1; SMN2GRK6NPC1L3MBTL1RAB9A | |
| SCHEMBL29712839 | 0.64 | METAP2 (0.42) | SMN1; SMN2PIEZO1GRK6NPC1ALDH1A1 | |
| SCHEMBL28634816 | 0.64 | METAP2 (0.42) | SMN1; SMN2PIEZO1GRK6NPC1ALDH1A1 | |
| SCHEMBL5484113 | 0.64 | SMN1; SMN2 (0.82) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL7486893 | 0.64 | PIEZO1 (0.47) | SMN1; SMN2PIEZO1NPC1ALDH1A1RAB9A | |
| SCHEMBL1927150 | 0.63 | KDM4E (0.47) | SMN1; SMN2GRK6NPC1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073726-A1 | Heterocyclic inhibitors of glycine transporter 2 | TELIK, INC. | 2003-04-17 | — | — | US | claimed |
| US-6894054-B2 | Heterocyclic inhibitors of glycine transporter 2 | TELIK, INC. (US) | 2005-05-17 | — | — | US | disclosed |
| US-20030073726-A1 | Heterocyclic inhibitors of glycine transporter 2 | TELIK, INC. | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073726-A1 | Heterocyclic inhibitors of glycine transporter 2 | SLC1A2, SLC1A1, SLC1A3 | SMN1; SMN2 210/4885LMNA 3529/4885PIEZO1 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.