Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489697 | 1.00 | LTA4H (0.44) | LTA4HEPHX2ALOX5PPARGPPARA | |
| SCHEMBL7803604 | 0.89 | MMP13 (0.43) | LTA4HEPHX2ALOX5LTB4RLTB4R2 | |
| SCHEMBL6491209 | 0.87 | LTA4H (0.48) | LTA4HEPHX2ALOX5PPARGPPARA | |
| SCHEMBL6178946 | 0.84 | ALOX5 (0.47) | ALOX5FFAR1FFAR4NR4A1NR4A2 | |
| SCHEMBL6178942 | 0.84 | ALOX5 (0.47) | ALOX5FFAR1FFAR4NR4A1NR4A2 | |
| SCHEMBL6176965 | 0.78 | ALOX5 (0.47) | ALOX5PPARGPPARAFFAR1FFAR4 | |
| SCHEMBL6176969 | 0.78 | ALOX5 (0.47) | ALOX5PPARGPPARAFFAR1FFAR4 | |
| SCHEMBL6178043 | 0.76 | NPC1 (0.54) | EPHX2ALOX5PPARGPPARA | |
| SCHEMBL6178029 | 0.76 | NPC1 (0.54) | EPHX2ALOX5PPARGPPARA | |
| SCHEMBL6490658 | 0.75 | ALOX5 (0.49) | ALOX5FFAR1FFAR4NR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881736-B1 | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1218005-B1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1218005-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1218005-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001017959-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-15 | — | — | WO | disclosed |