Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480317 | 0.86 | KMT2A (0.48) | KMT2AHPGDMEN1ALDH1A1MAPT | |
| SCHEMBL22060040 | 0.79 | EPHX2 (0.58) | KMT2AHPGDALOX15MEN1ALDH1A1 | |
| SCHEMBL14285632 | 0.73 | EPHX2 (0.73) | KMT2AHPGDALOX15MEN1EPHX2 | |
| SCHEMBL8468149 | 0.73 | LMNA (0.59) | ALOX15ADRB2ADRB1ADRB3 | |
| SCHEMBL2731803 | 0.73 | LMNA (0.59) | ALOX15ADRB2ADRB1ADRB3 | |
| SCHEMBL9283760 | 0.73 | LMNA (0.59) | ALOX15ADRB2ADRB1ADRB3 | |
| SCHEMBL5421055 | 0.73 | LMNA (0.59) | ALOX15ADRB2ADRB1ADRB3 | |
| SCHEMBL17547180 | 0.73 | CA12 (0.67) | KMT2AHPGDMEN1ALDH1A1MAPT | |
| SCHEMBL18643013 | 0.73 | CA12 (0.67) | KMT2AHPGDMEN1ALDH1A1MAPT | |
| SCHEMBL28138390 | 0.73 | CA12 (0.67) | KMT2AHPGDMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890955-B2 | Aryloxypropanolamine derivatives, method of preparation and applications thereof | VIRBAC SA (FR) | 2005-05-10 | — | — | US | disclosed |
| US-20030158259-A1 | Aryloxypropanolamine derivatives, method of preparation and applications thereof | VIRBAC SA | 2003-08-21 | — | — | US | disclosed |
| US-20020019440-A1 | Aryloxypropanolamine derivatives, method of preparation and applications thereof | VIRBAC SA | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019440-A1 | Aryloxypropanolamine derivatives, method of preparation and applications thereof | FABP4, CCNO, PAOX | KMT2A 1561/4885HPGD 558/4885ALOX15 383/4885 |
| US-20030158259-A1 | Aryloxypropanolamine derivatives, method of preparation and applications thereof | PAOX, ACOX3, FABP4 | KMT2A 1519/4885HPGD 843/4885ALOX15 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.