SCHEMBL6490243

SCHEMBL6490243

CCOc1ccc(S(=O)(=O)N2C[C@@H](C)N[C@@H](C)C2)cc1C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.49
ALDH1A1 P00352 2/20 0.47
LMNA P02545 2/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
GAA P10253 1/20 0.45
S1PR3 Q99500 1/20 0.45
NPC1 O15118 3/20 0.44
TSHR P16473 2/20 0.44
RAB9A P51151 1/20 0.43
ATM Q13315 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29897709 1.00 APEX1 (0.49) APEX1ALDH1A1LMNAHTTSMN1; SMN2
SCHEMBL6490246 1.00 APEX1 (0.49) APEX1ALDH1A1LMNAHTTSMN1; SMN2
SCHEMBL6491181 0.90 ALDH1A1 (0.46) ALDH1A1LMNAHTTSMN1; SMN2GAA
SCHEMBL29897705 0.90 ALDH1A1 (0.46) ALDH1A1LMNAHTTSMN1; SMN2GAA
SCHEMBL6491185 0.90 ALDH1A1 (0.46) ALDH1A1LMNAHTTSMN1; SMN2GAA
SCHEMBL15926140 0.88 APEX1 (0.49) APEX1ALDH1A1LMNAHTTSMN1; SMN2
SCHEMBL25926241 0.85 ALDH1A1 (0.41) ALDH1A1LMNAHTTSMN1; SMN2GAA
SCHEMBL25925529 0.84 ALDH1A1 (0.41) ALDH1A1LMNAHTTSMN1; SMN2GAA
SCHEMBL6691845 0.81 ALDH1A1 (0.44) ALDH1A1LMNAHTTSMN1; SMN2GAA
SCHEMBL6691847 0.81 LMNA (0.44) ALDH1A1LMNAHTTSMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113350301-B New compound traditional Chinese medicine honeyed pill for treating impotence 刘宝顺 2022-10-04 CN claimed
CN-113350301-A New compound traditional Chinese medicine honeyed pill for treating impotence 刘宝顺 2021-09-07 CN claimed
EP-1400522-B1 COMPOUNDS FOR TREATING IMPOTENCE GUANGZHOU YOUCARE BIOPHARMACEATICS CO LTD (CN) 2014-08-06 EP claimed
US-6960592-B2 1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compound for the treatment of impotence LIU BAOSHUN 2005-11-01 US claimed
US-20040152709-A1 New compound for the treatment of impotence LIU BAOSHUN (CN) 2004-08-05 US claimed
EP-1400522-A1 NEW COMPOUNDS FOR TREATING IMPOTENCE Liu, Baoshun (CN) 2004-03-24 EP claimed
US-20250041309-A1 USE OF AILDENAFIL OR SALT THEREOF IN PREPARATION OF MEDICINE FOR PREVENTING OR TREATING ISCHEMIC BRAIN DAMAGE ZHENAO JINYINHUA PHARMACEUTICAL (CN) 2025-02-06 US disclosed
WO-2023109513-A1 USE OF AILDENAFIL OR SALT THEREOF IN PREPARATION OF MEDICINE FOR PREVENTING OR TREATING ISCHEMIC BRAIN DAMAGE 真奥金银花药业有限公司 2023-06-22 WO disclosed
CN-113350301-B New compound traditional Chinese medicine honeyed pill for treating impotence 刘宝顺 2022-10-04 CN disclosed
CN-113350301-A New compound traditional Chinese medicine honeyed pill for treating impotence 刘宝顺 2021-09-07 CN disclosed
EP-1400522-B1 COMPOUNDS FOR TREATING IMPOTENCE GUANGZHOU YOUCARE BIOPHARMACEATICS CO LTD (CN) 2014-08-06 EP disclosed
EP-1400522-B1 COMPOUNDS FOR TREATING IMPOTENCE GUANGZHOU YOUCARE BIOPHARMACEATICS CO LTD (CN) 2014-08-06 EP disclosed
US-6960592-B2 1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compound for the treatment of impotence LIU BAOSHUN 2005-11-01 US disclosed
US-20040152709-A1 New compound for the treatment of impotence LIU BAOSHUN (CN) 2004-08-05 US disclosed
EP-1400522-A1 NEW COMPOUNDS FOR TREATING IMPOTENCE Liu, Baoshun (CN) 2004-03-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250041309-A1 USE OF AILDENAFIL OR SALT THEREOF IN PREPARATION OF MEDICINE FOR PREVENTING OR TREATING ISCHEMIC BRAIN DAMAGE PDE5A, PDE3A, PDE2A APEX1 3153/4885ALDH1A1 451/4885LMNA 753/4885
US-20040152709-A1 New compound for the treatment of impotence PDE3B, PDE3A, PDE5A APEX1 566/4885ALDH1A1 221/4885LMNA 2553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.