Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.45 |
| ▸ | PON1 | P27169 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274941 | 0.81 | POLB (0.57) | AKR1B1MCL1KDM4EHPGDGAA | |
| SCHEMBL30002655 | 0.81 | POLB (0.57) | AKR1B1MCL1KDM4EHPGDGAA | |
| SCHEMBL2403666 | 0.77 | RAB9A (0.59) | AKR1B1GPR35KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11128154 | 0.76 | NPC1 (0.55) | SMN1; SMN2CA12ALDH1A1MAPTALOX15 | |
| SCHEMBL10626736 | 0.76 | MAOB (0.61) | SMN1; SMN2CA12MAPTALOX15ACHE | |
| SCHEMBL2791740 | 0.76 | AKR1B1 (0.61) | AKR1B1MCL1GPR35PON1KDM4E | |
| SCHEMBL10845026 | 0.75 | CA12 (0.50) | AKR1B1KDM4ECA12GLACA9 | |
| SCHEMBL4150207 | 0.74 | CA12 (0.48) | AKR1B1CA12CA9MEN1NPC1 | |
| SCHEMBL8809509 | 0.74 | CA12 (0.35) | AKR1B1MCL1KDM4EHPGDGAA | |
| SCHEMBL29628919 | 0.74 | GPR35 (0.76) | GPR35KDM4ECA12ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951870-B2 | Coumarin derivatives with COMT inhibiting activity | ORION CORPORATION (FI) | 2005-10-04 | — | — | US | disclosed |
| CN-1199963-C | Coumarin derivatives with COMT inhibiting activity | ORION CORP (FI) | 2005-05-04 | — | — | CN | disclosed |
| US-20040110750-A9 | Coumarin derivatives with comt inhibiting activity | ORION CORPORATION (FI) | 2004-06-10 | — | — | US | disclosed |
| EP-1301503-B1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORP (FI) | 2004-02-25 | — | — | EP | disclosed |
| US-20030186975-A1 | Coumarin derivatives with comt inhibiting activity | PYSTYNEN JARMO (FI) | 2003-10-02 | — | — | US | disclosed |
| CN-1440399-A | Coumarin derivatives with COMT inhibiting activity | ORION CORP (FI) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301503-A1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORPORATION (FI) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002002548-A1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORPORATION (FI) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110750-A9 | Coumarin derivatives with comt inhibiting activity | COMT, CYP1A1, CYP2D6 | AKR1B1 136/4885MCL1 3402/4885GPR35 2731/4885 |
| US-20030186975-A1 | Coumarin derivatives with comt inhibiting activity | COMT, CYP1A1, CYP2D6 | AKR1B1 136/4885MCL1 3402/4885GPR35 2731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.