Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486970 | 0.92 | TMEM97 (0.41) | CYP2D6TMEM97SIGMAR1KDM4ETDP1 | |
| SCHEMBL6485467 | 0.90 | TMEM97 (0.37) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL6496169 | 0.89 | TMEM97 (0.48) | ALDH1A1TMEM97SIGMAR1HRH3MEN1 | |
| SCHEMBL6496625 | 0.85 | TMEM97 (0.45) | TMEM97SIGMAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6498604 | 0.85 | TMEM97 (0.34) | ALDH1A1CYP2D6TMEM97SIGMAR1MEN1 | |
| SCHEMBL6495646 | 0.85 | CYP19A1 (0.38) | CYP2D6TMEM97SIGMAR1 | |
| SCHEMBL6495793 | 0.84 | ALDH1A1 (0.41) | ALDH1A1CYP2D6SIGMAR1KDM4EMEN1 | |
| SCHEMBL6494147 | 0.84 | GRM5 (0.35) | ALDH1A1TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL6495760 | 0.84 | TMEM97 (0.44) | CYP2D6TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL6488679 | 0.83 | TMEM97 (0.39) | ALDH1A1CYP2D6TMEM97SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869958-B2 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-02-26 | — | — | US | disclosed |
| WO-2004014909-A1 | FUSED TETRAHYDROPYRIDINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | MMP9, MMP3, MMP13 | ALDH1A1 1071/4885CYP2D6 743/4885TMEM97 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.