Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.44 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500944 | 0.93 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| Cadaverine Tartrate SCHEMBL3542909 | 0.76 | SLC6A3 (0.48) | SLC6A2SLC6A4SLC6A3HTR6OPRM1 | |
| SCHEMBL6492685 | 0.75 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL3062717 | 0.73 | SLC6A4 (0.53) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL6498978 | 0.72 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL6490803 | 0.71 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL8108438 | 0.71 | HTR6 (0.50) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL5829818 | 0.70 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL5829151 | 0.70 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL2419033 | 0.69 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3HTR6HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964972-B2 | 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors | NEUROSEARCH A/S (DK) | 2005-11-15 | — | — | US | disclosed |