Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499575 | 0.88 | TDP1 (0.48) | ATMKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL5605136 | 0.84 | ATM (0.54) | ATMNPC1KDM4EALDH1A1TSHR | |
| SCHEMBL10983 | 0.82 | L3MBTL1 (0.62) | ATMNPC1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14500981 | 0.81 | ATM (0.82) | ATMNPC1KDM4EALDH1A1TSHR | |
| SCHEMBL5605768 | 0.81 | HSD11B1 (0.53) | ATMNPC1KDM4EALDH1A1TSHR | |
| SCHEMBL4497375 | 0.80 | ATM (0.48) | ATMNPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11928064 | 0.80 | L3MBTL1 (0.71) | ATMNPC1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL674349 | 0.80 | ATM (0.79) | ATMNPC1KDM4EALDH1A1TSHR | |
| SCHEMBL19754840 | 0.79 | ATM (0.48) | ATMNPC1KDM4EALDH1A1TSHR | |
| SCHEMBL16219483 | 0.79 | ATM (0.48) | ATMNPC1KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1255391-C | COLCHINOL derivatives as vascular damaging agents | ANGIOGENE PHARM LTD (GB) | 2006-05-10 | — | — | CN | disclosed |
| US-20050277627-A1 | Colchinol derivatives as vascular damaging agents | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2005-12-15 | — | — | US | disclosed |
| CN-1440395-A | COLCHINOL derivatives as vascular damaging agents | ANGIOGENE PHARM LTD (GB) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301497-A1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | Angiogene Pharmaceuticals Limited (GB) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004434-A1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277627-A1 | Colchinol derivatives as vascular damaging agents | TOP1, TDP1, TOP2B | ATM 1699/4885NPC1 1310/4885KDM4E 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.