SCHEMBL10983

SCHEMBL10983

CCCCC(=O)N1CCN(C(C)=O)CC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.62
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
TDP1 Q9NUW8 3/20 0.60
GNAI3 P08754 8/20 0.58
GNAI1 P63096 8/20 0.58
GNAO1 P09471 7/20 0.50
MAPT P10636 2/20 0.50
POLB P06746 1/20 0.50
ATM Q13315 1/20 0.50
NPC1 O15118 1/20 0.47
GPR183 P32249 1/20 0.47
CYP1A2 P05177 1/20 0.46
ALDH1A1 P00352 2/20 0.45
LMNA P02545 2/20 0.45
KDM4E B2RXH2 1/20 0.45
USP2 O75604 1/20 0.45
CYP3A4 P08684 1/20 0.45
HPGD P15428 1/20 0.45
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11928064 0.94 L3MBTL1 (0.71) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL673399 0.91
SCHEMBL12457130 0.87 TDP1 (0.50) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL6285463 0.85 L3MBTL1 (0.83) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL2134122 0.85 L3MBTL1 (0.83) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL27403214 0.83 L3MBTL1 (0.62) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL11240 0.83 L3MBTL1 (0.62) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL8972813 0.83 L3MBTL1 (0.80) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL4450061 0.83 L3MBTL1 (0.80) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL768398 0.83 L3MBTL1 (0.80) L3MBTL1MEN1KMT2ATDP1GNAI3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9834560-B2 Compounds RESPIVERT LTD. (GB) 2017-12-05 US disclosed
US-9580425-B2 Pyrido[3,4-b] indoles and methods of use MEDIVATION TECHNOLOGIES, INC. (US) 2017-02-28 US disclosed
US-20160264583-A1 COMPOUNDS RESPIVERT LTD. (GB) 2016-09-15 US disclosed
US-9321773-B2 Compounds Respivert, Ltd. (GB) 2016-04-26 US disclosed
US-20140249164-A1 COMPOUNDS RESPIVERT LTD (GB) 2014-09-04 US disclosed
US-8741909-B2 PI3 kinase inhibitors RESPIVERT LTD. (GB) 2014-06-03 US disclosed
WO-2011048111-A1 COMPOUNDS RESPIVERT LIMITED (GB) 2011-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160264583-A1 COMPOUNDS LTC4S, CYP11B2, LTB4R2 L3MBTL1 4133/4885MEN1 1550/4885KMT2A 3691/4885
US-20140249164-A1 COMPOUNDS LTC4S, CYP11B2, LTB4R2 L3MBTL1 4133/4885MEN1 1550/4885KMT2A 3691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.