Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17781830 | 0.82 | KMT2A (0.41) | GPR119DPP4DPP7MEN1KMT2A | |
| SCHEMBL651152 | 0.77 | RIPK1 (0.39) | DPP4DPP7MEN1KMT2ACHRM3 | |
| SCHEMBL19467730 | 0.75 | CCR5 (0.42) | KMT2ACHRM3KDM4E | |
| SCHEMBL3575935 | 0.75 | CCR5 (0.42) | KMT2ACHRM3KDM4E | |
| SCHEMBL3582255 | 0.75 | CCR5 (0.42) | KMT2ACHRM3KDM4E | |
| SCHEMBL7687290 | 0.75 | CCR5 (0.42) | KMT2ACHRM3KDM4E | |
| SCHEMBL5130929 | 0.75 | CCR5 (0.42) | KMT2ACHRM3KDM4E | |
| SCHEMBL3494682 | 0.75 | KMT2A (0.39) | MEN1KMT2ACHRM3 | |
| SCHEMBL1586795 | 0.74 | GPR119 (0.54) | GPR119KDM4E | |
| SCHEMBL1586797 | 0.74 | GPR119 (0.54) | GPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |