Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 5/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649412 | 0.77 | GPR119 (0.38) | KDM4EMEN1KMT2ADPP4CHRM3 | |
| SCHEMBL928365 | 0.75 | CHRM2 (0.35) | RIPK1MEN1KMT2ADPP4DPP8 | |
| SCHEMBL17821462 | 0.72 | KMT2A (0.42) | RIPK1KDM4EMEN1KMT2ACYP2D6 | |
| SCHEMBL28429419 | 0.70 | KMT2A (0.40) | RIPK1FKBP1AMEN1KMT2AHTT | |
| SCHEMBL3494682 | 0.69 | KMT2A (0.39) | MEN1KMT2ACHRM3 | |
| SCHEMBL17781830 | 0.68 | KMT2A (0.41) | FKBP1AMEN1KMT2ADPP4CHRM3 | |
| SCHEMBL2014668 | 0.68 | KMT2A (0.39) | MEN1KMT2A | |
| SCHEMBL4899270 | 0.68 | KMT2A (0.56) | KDM4EMEN1KMT2ACYP2D6 | |
| SCHEMBL2017923 | 0.68 | KMT2A (0.38) | MEN1KMT2ACCR5CYP2D6 | |
| SCHEMBL2014085 | 0.68 | KMT2A (0.38) | FKBP1AKDM4EMEN1KMT2ACCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |