Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.67 |
| ▸ | CA12 | O43570 | 3/20 | 0.67 |
| ▸ | CA7 | P43166 | 2/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.67 |
| ▸ | STS | P08842 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926757 | 0.86 | CA12 (0.51) | CA1CA12CA7CA14STS | |
| SCHEMBL30193288 | 0.83 | CTSS (0.64) | ATMAKT1HPGDMEN1ALDH1A1 | |
| SCHEMBL20379753 | 0.82 | HPGD (0.59) | CA1CA12CA7CA14STS | |
| SCHEMBL6337412 | 0.80 | CA12 (1.00) | CA1CA12CA7CA14CA2 | |
| SCHEMBL12862920 | 0.80 | CA1 (0.55) | CA1CA12CA7CA14STS | |
| SCHEMBL7464176 | 0.80 | PPARA (0.56) | CA1CA12CA7CA14ATM | |
| SCHEMBL7464166 | 0.80 | PPARA (0.56) | CA1CA12CA7CA14ATM | |
| SCHEMBL15779079 | 0.79 | GAA (0.54) | CA1CA12CA2MMP1MMP2 | |
| SCHEMBL7709249 | 0.79 | CA2 (0.56) | CA2MAPTMEN1ALDH1A1LMNA | |
| SCHEMBL8244755 | 0.78 | CA12 (0.75) | CA1CA12CA7CA14CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069976-A | A kind of nitrogenous macrocyclic compounds, its preparation method, pharmaceutical composition and application | 山东罗欣药业集团股份有限公司 | 2018-05-25 | — | — | CN | disclosed |
| US-6855725-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040063749-A1 | Excitatory amino acid receptor antagonists | BLEISCH THOMAS JOHN (US) | 2004-04-01 | — | — | US | disclosed |
| EP-1351952-A2 | PYRROLIDINYLMETHYL SUBSTITUTED DECAHYDROISOQUINOLINES AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002053556-A2 | PYRROLIDINYLMETHYL SUBSTITUTED DECAHYDROISOQUINOLINES AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063749-A1 | Excitatory amino acid receptor antagonists | SLC1A2, SLC1A1, SLC1A3 | CA1 946/4885CA12 2725/4885CA7 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.