Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972849 | 0.95 | LMNA (0.59) | MAPTSMN1; SMN2LMNACYP2C19CRHBP | |
| SCHEMBL6489911 | 0.84 | PLA2G10 (0.54) | MAPTCYP2C19MEN1KMT2ACNR2 | |
| SCHEMBL6500068 | 0.83 | HSD17B1 (0.52) | LMNACYP2C19CRHBPCRHR2MEN1 | |
| SCHEMBL7154167 | 0.82 | CYP2C19 (0.69) | SMN1; SMN2LMNACYP2C19CRHBPCRHR2 | |
| SCHEMBL653857 | 0.81 | CYP2C19 (0.58) | CYP2C19CRHBPCRHR2MEN1KMT2A | |
| SCHEMBL11353086 | 0.81 | CYP2C19 (0.58) | CYP2C19CRHBPCRHR2MEN1KMT2A | |
| Butane SCHEMBL21981222 | 0.79 | CYP2C19 (0.56) | CYP2C19CRHBPCRHR2MEN1KMT2A | |
| SCHEMBL9474642 | 0.78 | LMNA (0.89) | MAPTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL7741913 | 0.78 | MAPT (0.70) | MAPTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL15725683 | 0.78 | MAPT (0.70) | MAPTSMN1; SMN2LMNAALDH1A1HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065195-A1 | Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065195-A1 | Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors | MAPK3, MAPK1, MAPKAPK3 | MAPT 1599/4885SMN1; SMN2 2463/4885LMNA 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.