Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20470517 | 0.76 | CYP11B2 (0.55) | CYP11B2CHEK2FDPS | |
| SCHEMBL6505188 | 0.72 | POLB (0.41) | PKML3MBTL1 | |
| SCHEMBL268819 | 0.71 | L3MBTL1 (0.50) | L3MBTL1 | |
| SCHEMBL8716866 | 0.71 | KMT2A (0.56) | PKML3MBTL1 | |
| SCHEMBL766565 | 0.69 | L3MBTL1 (0.58) | L3MBTL1 | |
| SCHEMBL25544943 | 0.69 | HCAR2 (0.56) | KDRDCLRE1BCYP11B2DYRK1ACLK2 | |
| SCHEMBL31475536 | 0.69 | HCAR2 (0.56) | KDRDCLRE1BCYP11B2DYRK1ACLK2 | |
| SCHEMBL1336193 | 0.68 | CYP2C9 (0.48) | L3MBTL1 | |
| SCHEMBL5429719 | 0.68 | HPGD (0.49) | KDRCYP11B2DYRK1ACLK2CHEK2 | |
| SCHEMBL24038372 | 0.68 | CYP11B2 (0.60) | KDRCYP11B2DYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960599-B2 | Heterocyclic aminoalkylpyridine derivatives as psychopharmaceuticals | MERCK PATENT GMBH (DE) | 2005-11-01 | — | — | US | disclosed |
| US-20040019044-A1 | Heterocyclic aminoalkyl pyridine derivatives as psychopharmaceuticals | MERCK PATENT GMBH (DE) | 2004-01-29 | — | — | US | disclosed |
| CN-1437595-A | Heterocyclic aminoalkyl pyridine derivatives as psychopharmaceuticals | MERCK PATENT GMBH (DE) | 2003-08-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019044-A1 | Heterocyclic aminoalkyl pyridine derivatives as psychopharmaceuticals | HTR4, CNR1, CNR2 | PKM 2527/4885ROCK2 3600/4885PRMT6 3708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.