Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154167 | 0.88 | CYP2C19 (0.69) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL9320026 | 0.82 | CYP2C19 (0.62) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL2960872 | 0.82 | CYP2C19 (0.78) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL12763733 | 0.81 | CYP2C19 (0.85) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL5369717 | 0.81 | CYP2C19 (0.60) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL18814251 | 0.79 | TAAR1 (0.75) | TAAR1CYP2C19LOXL2HRH3TSHR | |
| SCHEMBL10763738 | 0.78 | CYP2C19 (0.67) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL4407604 | 0.78 | CYP2C19 (0.67) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL11334293 | 0.78 | CYP2C19 (0.56) | TAAR1CYP2C19CNR2TSHRNR1H2 | |
| SCHEMBL43183 | 0.77 | TSHR (0.74) | TAAR1CYP2C19CNR2TSHRNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065195-A1 | Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065195-A1 | Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors | MAPK3, MAPK1, MAPKAPK3 | TAAR1 2654/4885CYP2C19 397/4885LOXL2 1635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.