Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB2 | P47870 | 4/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18003369 | 0.86 | IDO1 (0.59) | GABRB2GABRA2SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1314013 | 0.85 | RAB9A (0.53) | SMN1; SMN2ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL2225245 | 0.81 | HPGDS (0.50) | ALDH1A1MAPTLMNANPC1RAB9A | |
| SCHEMBL14190000 | 0.80 | HPGDS (0.49) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL4879887 | 0.78 | COMT (0.49) | SMN1; SMN2MAPTNPC1RAB9ACYP11B1 | |
| SCHEMBL28720076 | 0.78 | IDO1 (0.45) | GABRB2GABRA2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18356513 | 0.78 | HPGDS (0.44) | ALDH1A1MAPTLMNANPC1RAB9A | |
| SCHEMBL10961092 | 0.77 | L3MBTL1 (0.48) | GABRB2GABRA2SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL10992502 | 0.77 | ESR1 (0.48) | GABRB2GABRA2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8669626 | 0.76 | MAP4K4 (0.48) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |