Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 0.65 |
| ▸ | RAB9A | P51151 | 15/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.65 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713412 | 0.82 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL1500539 | 0.81 | NOTUM (0.61) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL225236 | 0.81 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL2833417 | 0.81 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL46426 | 0.81 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL4343181 | 0.79 | NPC1 (0.94) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL27887069 | 0.78 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL28402300 | 0.77 | ATR (0.76) | — | |
| SCHEMBL22858502 | 0.77 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL46424 | 0.77 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2ATAD2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977263-B2 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-20 | — | — | US | disclosed |