SCHEMBL649911

SCHEMBL649911

O=C(Nc1ccc(Cl)cc1)c1cc(Cl)cc(Cl)c1O

nearest known ligand 0.77

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.77
TBXAS1 P24557 1/20 0.77
MAPK1 P28482 1/20 0.77
PTGS2 P35354 1/20 0.77
MAPK14 Q16539 1/20 0.77
STK39 Q9UEW8 11/20 0.70
PNLIP P16233 1/20 0.69
P2RX1 P51575 1/20 0.66
PARG Q86W56 3/20 0.64
BCL2L1 Q07817 1/20 0.60
CTSD P07339 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29375129 1.00 PTGS1 (0.77) PTGS1TBXAS1MAPK1PTGS2MAPK14
SCHEMBL21570088 0.91 STK39 (0.85) PTGS1TBXAS1MAPK1PTGS2MAPK14
SCHEMBL11692717 0.89 PTGS1 (0.71) PTGS1TBXAS1MAPK1PTGS2MAPK14
SCHEMBL10457403 0.89 PARG (0.71) PTGS1TBXAS1MAPK1PTGS2MAPK14
SCHEMBL25413048 0.89 PTGS1 (0.71) PTGS1TBXAS1MAPK1PTGS2MAPK14
SCHEMBL9868077 0.89 STK39 (0.77) PTGS1TBXAS1MAPK1PTGS2MAPK14
3,3',4',5-Tetrachlorosalicylanilide SCHEMBL29367227 0.87 PTGS1 (1.00) PTGS1TBXAS1MAPK1PTGS2MAPK14
3,3',4',5-Tetrachlorosalicylanilide SCHEMBL168748 0.87 PTGS1 (1.00) PTGS1TBXAS1MAPK1PTGS2MAPK14
Hydrochloric Acid SCHEMBL11777767 0.87 STK39 (0.75) PTGS1TBXAS1MAPK1PTGS2MAPK14
SCHEMBL29211122 0.85 P2RX1 (0.64) PTGS1TBXAS1MAPK1PTGS2MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 225 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150056160-A1 CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA TEXAS PHARMACEUTICALS, INC. 2015-02-26 US claimed
EP-2313026-A1 ACTIVE DELIVERY SYSTEM FORMULATIONS Castle Beach, L.L.C. (US) 2011-04-27 EP claimed
US-20100040565-A1 ACTIVE DELIVERY SYSTEMS FORMULATIONS Castle Beach, LLC (US) 2010-02-18 US claimed
WO-2010019680-A1 ACTIVE DELIVERY SYSTEM FORMULATIONS HOMOLA ANDREW M (US) 2010-02-18 WO claimed
WO-2010008737-A2 ANTIMICROBIAL FLUID HANDLING DEVICES AND METHODS OF MANUFACTURE PELICAN GROUP HOLDINGS, INC. (US) 2010-01-21 WO claimed
EP-1458419-B1 ANTIMICROBIAL CONTACT LENS CASE NOVARTIS AG (CH) 2005-05-04 EP claimed
EP-1458419-A1 ANTIMICROBIAL CONTACT LENS CASE Novartis AG (CH) 2004-09-22 EP claimed
EP-0805672-B1 METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH HOMOLA ANDREW M (US) 2004-08-25 EP claimed
US-20030176530-A1 Antimicrobial contact lens case LINDLEY KAREN FRANCES (US) 2003-09-18 US claimed
EP-1098641-A4 CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA ST JUDE PHARMACEUTICALS INC (US) 2003-08-27 EP claimed
WO-2003049776-A1 ANTIMICROBIAL CONTACT LENS CASE NOVARTIS AG (CH) 2003-06-19 WO claimed
EP-1098641-A1 CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA Texas Pharmaceuticals, Inc. (US) 2001-05-16 EP claimed
WO-2000006143-A1 CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA TEXAS PHARMACEUTICALS, INC. (US) 2000-02-10 WO claimed
US-5665333-A Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth PROVSEAL LLC 1997-09-09 US claimed
US-4022880-A ZINC IONS, 3,4,5-TRIBROMO-SALICYLANILIDE, QUATERNARY AMMONIUM COMPOUNDS LEVER BROTHERS COMPANY (US) 1977-05-10 US claimed
EP-3528776-B1 REDUCED-ETHANOL MOUTH RINSE FORMULATIONS KENVUE BRANDS LLC (US) 2025-11-26 EP disclosed
EP-4551195-A1 CANNABINOID LIPID PREMIXTURE Fertin Pharma A/S (DK) 2025-05-14 EP disclosed
US-4022880-A ZINC IONS, 3,4,5-TRIBROMO-SALICYLANILIDE, QUATERNARY AMMONIUM COMPOUNDS LEVER BROTHERS COMPANY (US) 1977-05-10 US disclosed
US-4010252-A POLYQUATERNARY AMMONIUM COMPOUND, DEODORANTS COLGATE-PALMOLIVE COMPANY (US) 1977-03-01 US disclosed
US-3956510-A NESTING, CYLINDERS, LOOPS BEALL NELSON J 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100040565-A1 ACTIVE DELIVERY SYSTEMS FORMULATIONS LIPA, MMP7, CTSA PTGS1 328/4885TBXAS1 388/4885MAPK1 4317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.