Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563521 | 0.90 | GAA (0.45) | GAANPSR1L3MBTL1POLBALDH1A1 | |
| SCHEMBL18377407 | 0.85 | GAA (0.48) | GAANPSR1L3MBTL1POLBALDH1A1 | |
| SCHEMBL942807 | 0.81 | TSHR (0.54) | GAANPSR1L3MBTL1POLBALDH1A1 | |
| SCHEMBL29485565 | 0.80 | ALDH1A1 (0.47) | GAANPSR1L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL7394140 | 0.80 | NLRP3 (0.57) | GAANPSR1L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL7386523 | 0.78 | ATM (0.47) | GAANPSR1L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL7028752 | 0.78 | ALDH1A1 (0.58) | GAANPSR1L3MBTL1POLBALDH1A1 | |
| SCHEMBL4853186 | 0.78 | ALDH1A1 (0.45) | GAANPSR1L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL2346864 | 0.77 | GAA (0.77) | GAANPSR1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8194998 | 0.76 | CD69 (0.46) | GAANPSR1L3MBTL1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | PPARD, PPARG, PPARA | GAA 2179/4885NPSR1 2104/4885L3MBTL1 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.