Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 9/20 | 0.51 |
| ▸ | PRKCA | P17252 | 8/20 | 0.51 |
| ▸ | PRKCH | P24723 | 5/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.51 |
| ▸ | CDK4 | P11802 | 4/20 | 0.51 |
| ▸ | CCND1 | P24385 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.51 |
| ▸ | PRKACG | P22612 | 3/20 | 0.51 |
| ▸ | PRKACB | P22694 | 3/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510343 | 0.90 | PRKCB (0.46) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL6982683 | 0.83 | PRKCB (0.67) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL7815290 | 0.77 | PRKCB (0.60) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL9085670 | 0.77 | HTR1D (0.44) | SIRT2KDR | |
| SCHEMBL7822805 | 0.73 | PRKCB (0.74) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL7814978 | 0.73 | MAOA (0.58) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL9084320 | 0.73 | MEN1 (0.45) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL9084178 | 0.73 | PRKCB (0.60) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| Ro-316233 SCHEMBL624896 | 0.71 | PRKCB (1.00) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| Ro-316233 SCHEMBL29373011 | 0.71 | PRKCB (1.00) | PRKCBPRKCAPRKCHPRKCEPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014584-A1 | 3-(INDOL-1-YL)-4-(INDOL-3-YL)-PYRROLE-2,5-DIONES,3-(BENZIMIDAZOL-1-YL)-4-(INDOL-3-YL)-PYRROLE-2,5-DIONES, AND 3-(INDOLIN-1-YL)-4-(INDOL-3-YL)-PYRROLE-2,5-DIONES; THEIR PREPARATION AND USE AS MODULATORS OF APOPTOSIS | AEGERA THERAPEUTICS INC. (CA) | 2005-02-17 | — | — | WO | disclosed |