Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 6/20 | 0.42 |
| ▸ | AR | P10275 | 11/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24939780 | 0.80 | NOTUM (0.44) | XPO1AR | |
| SCHEMBL94147 | 0.76 | MGLL (0.46) | — | |
| SCHEMBL27920612 | 0.75 | KAT2B (0.37) | XPO1 | |
| SCHEMBL28434063 | 0.75 | MGLL (0.53) | — | |
| SCHEMBL24939862 | 0.75 | PIM3 (0.41) | — | |
| SCHEMBL96043 | 0.73 | MGLL (0.52) | XPO1 | |
| SCHEMBL5699260 | 0.72 | L3MBTL1 (0.43) | XPO1 | |
| SCHEMBL1116215 | 0.71 | KMT2A (0.41) | — | |
| SCHEMBL3686454 | 0.71 | KMT2A (0.41) | — | |
| SCHEMBL8142750 | 0.71 | MGLL (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861432-B2 | Piperazine derivatives that destabilize androgen receptors | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-03-01 | — | — | US | disclosed |