Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651341 | 0.93 | CRHR1 (0.42) | CRHR1PIN1LTB4R2C5AR1LPAR1 | |
| SCHEMBL648691 | 0.93 | RORC (0.41) | CRHR1C5AR1TSHRNR1H3 | |
| SCHEMBL650306 | 0.92 | CRHR1 (0.38) | CRHR1C5AR1TSHRAGTR1LPAR1 | |
| SCHEMBL1913039 | 0.90 | CRHR1 (0.47) | CRHR1PIN1LTB4R2C5AR1TSHR | |
| SCHEMBL649676 | 0.87 | CRHR1 (0.41) | CRHR1C5AR1 | |
| SCHEMBL648626 | 0.87 | PIN1 (0.38) | CRHR1PIN1MDM2LPAR1LPAR5 | |
| SCHEMBL650510 | 0.86 | PIN1 (0.41) | CRHR1PIN1C5AR1MDM2 | |
| SCHEMBL652369 | 0.85 | CRHR1 (0.40) | CRHR1AGTR1LPAR1LPAR5 | |
| SCHEMBL650214 | 0.85 | C5AR1 (0.51) | CRHR1C5AR1TSHR | |
| SCHEMBL651627 | 0.84 | PTGES (0.42) | CRHR1LTB4R2C5AR1MDM2LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |