Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320762 | 1.00 | TDP1 (0.34) | TDP1SCN1ASCN2ASCN3ADYRK3 | |
| SCHEMBL3320759 | 1.00 | TDP1 (0.34) | TDP1SCN1ASCN2ASCN3ADYRK3 | |
| SCHEMBL5142163 | 1.00 | TDP1 (0.34) | TDP1SCN1ASCN2ASCN3ADYRK3 | |
| SCHEMBL3886872 | 0.81 | ALDH1A1 (0.33) | TDP1SCN1ASCN2ASCN3AALDH1A1 | |
| SCHEMBL28496084 | 0.81 | ALDH1A1 (0.33) | TDP1SCN1ASCN2ASCN3AALDH1A1 | |
| SCHEMBL20888313 | 0.75 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL20888312 | 0.73 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL9186280 | 0.69 | TDP1 (0.40) | TDP1SCN1ASCN2ASCN3AALDH1A1 | |
| SCHEMBL6939096 | 0.66 | TDP1 (0.38) | TDP1SCN1ASCN2ASCN3AALDH1A1 | |
| SCHEMBL19994041 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124652-A1 | Guanidino compounds | BOYCE RUSTUM (US) | 2005-06-09 | — | — | US | disclosed |
| EP-1478626-A2 | GUANIDINO COMPOUNDS | CHIRON CORPORATION (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20030195187-A1 | Guanidino compounds | CHIRON CORPORATION | 2003-10-16 | — | — | US | disclosed |
| WO-2003066597-A2 | GUANIDINO COMPOUNDS | CHIRON CORPORATION (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195187-A1 | Guanidino compounds | MC4R, MC2R, GPR4 | TDP1 3646/4885SCN1A 2084/4885SCN2A 2578/4885 |
| US-20050124652-A1 | Guanidino compounds | MC4R, MC2R, GPR4 | TDP1 3646/4885SCN1A 2084/4885SCN2A 2578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.