Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 6/20 | 0.86 |
| ▸ | FAAH | O00519 | 6/20 | 0.49 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509148 | 0.93 | CCR8 (1.00) | CCR8MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6506653 | 0.90 | CCR8 (0.70) | CCR8FAAHKDM4EALDH1A1TDP1 | |
| SCHEMBL7064954 | 0.90 | CCR8 (0.70) | CCR8FAAHKDM4EALDH1A1TDP1 | |
| SCHEMBL7065039 | 0.89 | CCR8 (0.68) | CCR8FAAHKDM4EALDH1A1TDP1 | |
| SCHEMBL6509206 | 0.85 | CCR8 (0.64) | CCR8FAAHKDM4EALDH1A1TDP1 | |
| SCHEMBL6507972 | 0.84 | CCR8 (0.63) | CCR8FAAHMMP1MMP9MMP13 | |
| SCHEMBL6501296 | 0.84 | CCR8 (0.86) | CCR8MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7070871 | 0.84 | CCR8 (0.84) | CCR8FAAHMMP1MMP9MMP13 | |
| SCHEMBL7063399 | 0.83 | CCR8 (0.83) | CCR8MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6498159 | 0.81 | CCR8 (0.59) | CCR8FAAHKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | CCR8 1/4885FAAH 664/4885MMP1 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.