Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.31 |
| ▸ | MARK3 | P27448 | 2/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | CLK2 | P49760 | 2/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.31 |
| ▸ | NEK4 | P51957 | 2/20 | 0.31 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.31 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651503 | 0.82 | GRIN2B (0.35) | FNTAFNTBBCHEGSK3BCRHR1 | |
| SCHEMBL650210 | 0.81 | CNR2 (0.33) | ITKMAP4K4PHKG2MARK3CSNK1A1 | |
| SCHEMBL1913025 | 0.81 | C5AR1 (0.41) | FNTAFNTBBCHECNR2ACHE | |
| SCHEMBL648105 | 0.76 | C5AR1 (0.38) | BCHECNR2ALDH1A1LMNA | |
| SCHEMBL650483 | 0.76 | AGTR1 (0.35) | — | |
| SCHEMBL648737 | 0.75 | TSHR (0.37) | LTB4R2ALDH1A1 | |
| SCHEMBL652416 | 0.74 | ADRA1D (0.37) | CNR2 | |
| SCHEMBL651698 | 0.73 | NPC1 (0.36) | BCHEITKCNR2ALDH1A1LMNA | |
| SCHEMBL14572934 | 0.73 | PDK1 (0.40) | LTB4R2TDP1 | |
| SCHEMBL650630 | 0.73 | MKNK1 (0.36) | ITKALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |