Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 2/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650170 | 0.86 | TRPA1 (0.37) | GRIN2BTRPA1BRD4MEN1KMT2A | |
| SCHEMBL650211 | 0.82 | FNTA (0.37) | GSK3BFNTAFNTBCRHR1BCHE | |
| SCHEMBL650156 | 0.81 | C5AR1 (0.42) | GRIN2BROCK2JAK2GSK3BROCK1 | |
| SCHEMBL14572949 | 0.76 | TRPA1 (0.38) | GRIN2BTRPA1ROCK2MEN1KMT2A | |
| SCHEMBL648238 | 0.76 | C5AR1 (0.38) | GRIN2BROCK2JAK2MEN1KMT2A | |
| SCHEMBL648229 | 0.75 | TRPA1 (0.39) | GRIN2BTRPA1ROCK2BRD4MEN1 | |
| SCHEMBL650169 | 0.74 | MEN1 (0.37) | TRPA1MEN1KMT2AS1PR1 | |
| SCHEMBL650605 | 0.74 | TRPA1 (0.38) | GRIN2BTRPA1ROCK2GSK3BBRD4 | |
| SCHEMBL652764 | 0.74 | TRPA1 (0.38) | TRPA1ROCK2GSK3BMEN1KMT2A | |
| SCHEMBL650190 | 0.73 | ROCK2 (0.38) | TRPA1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357478-B2 | Polyamide compound and pharmaceutical composition for treating mitochondrial genetic diseases | TRIPLEX THERAPEUTICS INC. (JP) | 2019-07-23 | — | — | US | claimed |
| US-20170071912-A1 | Polyamide Compound and Pharmaceutical Composition for Treating Mitochondrial Genetic Diseases | TRIPLEX THERAPEUTICS INC. (JP) | 2017-03-16 | — | — | US | claimed |
| US-9518152-B2 | Polyamide compound and pharmaceutical composition for treating mitochondrial genetic disease | Yano, Takamitsu (JP) | 2016-12-13 | — | — | US | claimed |
| US-20150191571-A1 | POLYAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION FOR TREATING MITOCHONDRIAL GENETIC DISEASE | KNC LABORATORIES CO., LTD. (JP) | 2015-07-09 | — | — | US | claimed |
| EP-2692862-A1 | POLYAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION FOR TREATING MITOCHONDRIAL GENETIC DISEASES | Yano, Takamitsu (JP) | 2014-02-05 | — | — | EP | claimed |
| US-8278047-B2 | Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment | NABSYS, INC. (US) | 2012-10-02 | — | — | US | claimed |
| US-7087378-B1 | Design, synthesis and use of specific polyamide DNA-binding ligands | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2006-08-08 | — | — | US | claimed |
| US-6958240-B1 | Inhibition of major groove DNA binding proteins by modified polyamides | CALIFORNIA INSTIUTE OF TECHNOLOGY (US) | 2005-10-25 | — | — | US | claimed |
| US-6472537-B1 | POLYMERS FROM PRIMARY AMINE AND CARBOXYLIC ACID SUBSTITUTED PYROLE, HYDROXYPYROLE AND IMIDAZOLE MONOMERS AND HAVING 4-AMINOBUTYRIC ACID LINKER FORMING HAIRPIN TURNS AND OPTION-ALLY AMINO ACID RESIDUES; BINDING TO SPECIFIC | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-10-29 | — | — | US | claimed |
| US-20250250567-A1 | PROTOZOA TRANSCRIPTION FACTOR INHIBITOR | THE UNIVERSITY OF TOKYO (JP) | 2025-08-07 | — | — | US | disclosed |
| CN-119677513-A | Methods and compounds for modulating genetic disease | 设计治疗公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-119584961-A | Methods and compounds for modulating huntington's disease | 设计治疗公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-117279636-A | Methods and compounds for modulating myotonic muscular dystrophy type 1 | 设计治疗公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117241805-A | Methods and compounds for treating friedel-crafts ataxia | 设计治疗公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-1998037066-A9 | IMPROVED POLYAMIDES FOR BINDING IN THE MINOR GROOVE OF DOUBLE STRANDED DNA | — | 1999-02-04 | — | — | WO | disclosed |
| WO-1998037067-A1 | DESIGN, SYNTHESIS AND USE OF SPECIFIC POLYAMIDE DNA-BINDING LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-08-27 | — | — | WO | disclosed |
| WO-1998037066-A1 | IMPROVED POLYAMIDES FOR BINDING IN THE MINOR GROOVE OF DOUBLE STRANDED DNA | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-08-27 | — | — | WO | disclosed |
| WO-1998037066-A1 | IMPROVED POLYAMIDES FOR BINDING IN THE MINOR GROOVE OF DOUBLE STRANDED DNA | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-08-27 | — | — | WO | disclosed |
| WO-1998037067-A1 | DESIGN, SYNTHESIS AND USE OF SPECIFIC POLYAMIDE DNA-BINDING LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-08-27 | — | — | WO | disclosed |
| WO-1998035702-A1 | INHIBITION OF GENE TRANSCRIPTION BY POLYAMIDE DNA-BINDING LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191571-A1 | POLYAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION FOR TREATING MITOCHONDRIAL GENETIC DISEASE | POLRMT, TFAM, MT-ATP8 | GRIN2B 2320/4885TRPA1 4281/4885ROCK2 3996/4885 |
| US-10357478-B2 | Polyamide compound and pharmaceutical composition for treating mitochondrial genetic diseases | POLRMT, TFAM, MT-ATP8 | GRIN2B 2459/4885TRPA1 4226/4885ROCK2 3970/4885 |
| US-20170071912-A1 | Polyamide Compound and Pharmaceutical Composition for Treating Mitochondrial Genetic Diseases | POLRMT, TFAM, MT-ATP8 | GRIN2B 2459/4885TRPA1 4226/4885ROCK2 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.