Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493594 | 0.80 | ITGB3 (0.43) | ITGB3ITGAVITGA4ITGB1ITGA2B | |
| SCHEMBL6493907 | 0.79 | ITGB3 (0.42) | ITGB3ITGAVITGA4ITGB1ITGA2B | |
| SCHEMBL6503598 | 0.77 | ITGB1 (0.37) | ITGB3ITGAVITGA4ITGB1ITGA2B | |
| SCHEMBL5204549 | 0.73 | ITGB3 (0.37) | ITGB3ITGAVITGA2BMEN1CYP3A4 | |
| SCHEMBL5202520 | 0.73 | ITGB3 (0.37) | ITGB3ITGAVKMT2AHSD17B10 | |
| SCHEMBL5207840 | 0.71 | MAPT (0.32) | ITGB3ITGAVITGB1LMNAMAPT | |
| SCHEMBL14431254 | 0.71 | MAPT (0.32) | ITGB3ITGAVITGB1LMNAMAPT | |
| SCHEMBL6494232 | 0.67 | MAPT (0.30) | MAPT | |
| SCHEMBL6495275 | 0.66 | ITGB3 (0.36) | ITGB3ITGAVITGA4ITGB1ITGA2B | |
| SCHEMBL6495566 | 0.63 | FFAR1 (0.43) | LMNACYP3A4CYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |