Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 4/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431254 | 0.94 | MAPT (0.32) | ITGB1ITGA5ITGB3ITGAVTYR | |
| SCHEMBL5207840 | 0.94 | MAPT (0.32) | ITGB1ITGA5ITGB3ITGAVTYR | |
| SCHEMBL6495275 | 0.89 | ITGB3 (0.36) | ITGB1ITGA5ITGB3ITGAVTYR | |
| SCHEMBL5203778 | 0.83 | ITGB3 (0.32) | ITGB3ITGAV | |
| SCHEMBL14431255 | 0.81 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGAVTYR | |
| SCHEMBL3048694 | 0.81 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGAVTYR | |
| SCHEMBL6498071 | 0.79 | ITGB3 (0.44) | ITGB3ITGAVTYRITGA2BPPARG | |
| SCHEMBL3052420 | 0.79 | ITGB3 (0.44) | ITGB3ITGAVTYRITGA2BPPARG | |
| SCHEMBL6502618 | 0.78 | TYR (0.44) | ITGB3ITGAVTYRITGA2BPPARG | |
| SCHEMBL6502342 | 0.77 | ITGB3 (0.36) | ITGB1ITGB3ITGAVITGA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |