Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431254 | 1.00 | MAPT (0.32) | MAPTITGB3ITGAVITGB1ITGA5 | |
| SCHEMBL6503598 | 0.94 | ITGB1 (0.37) | MAPTITGB3ITGAVITGB1ITGA5 | |
| SCHEMBL5203778 | 0.89 | ITGB3 (0.32) | ITGB3ITGAV | |
| SCHEMBL6495275 | 0.83 | ITGB3 (0.36) | ITGB3ITGAVITGB1ITGA5TYR | |
| SCHEMBL5207016 | 0.82 | ITGB1 (0.42) | ITGB3ITGAVITGB1ITGA5TYR | |
| SCHEMBL14431257 | 0.82 | ITGB1 (0.42) | ITGB3ITGAVITGB1ITGA5TYR | |
| SCHEMBL5206753 | 0.80 | ALOX15 (0.39) | MAPTITGB3ITGAVTYRKDM4E | |
| SCHEMBL5202544 | 0.78 | ITGB3 (0.31) | ITGB3ITGAV | |
| SCHEMBL5205119 | 0.78 | ITGB3 (0.38) | ITGB3ITGAVTYRKDM4ELMNA | |
| SCHEMBL5210309 | 0.78 | TYR (0.41) | ITGB3ITGAVTYRKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1124824-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026212-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-05-11 | — | — | WO | disclosed |