Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | GNG2 | P59768 | 1/20 | 0.40 |
| ▸ | GNB1 | P62873 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079845 | 0.84 | MEN1 (0.43) | PRKCIMEN1KMT2AKIF11HTT | |
| SCHEMBL21816666 | 0.82 | PRKCI (0.51) | PRKCIMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3554231 | 0.82 | S1PR2 (0.56) | PRKCIMEN1KMT2ALMNANPC1 | |
| SCHEMBL11175103 | 0.81 | KIF11 (0.66) | MEN1KMT2AKIF11HTTPEPD | |
| SCHEMBL6079794 | 0.81 | MEN1 (0.41) | PRKCIMEN1KMT2AKIF11HTT | |
| SCHEMBL12685297 | 0.80 | LMNA (0.56) | PRKCIMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL10616487 | 0.78 | MAPT (0.58) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL1787750 | 0.78 | PEPD (0.56) | MEN1KMT2AKIF11PEPDALDH1A1 | |
| SCHEMBL5186798 | 0.77 | MGLL (0.47) | KIF11NPC1POLBRAD52CYP1A2 | |
| SCHEMBL30801673 | 0.77 | KIF11 (0.50) | MEN1KMT2AKIF11PEPDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005051381-A1 | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) | BIOVITRUM AB (SE) | 2005-06-09 | — | — | WO | claimed |
| CN-1856305-B | Pyridine derivatives as urotensin II antagonists | ACTELION PHARMACEUTICALS LTD | 2010-04-28 | — | — | CN | disclosed |
| CN-1856305-A | Pyridine derivatives and their use as urotensin II antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2006-11-01 | — | — | CN | disclosed |