Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 8/20 | 0.87 |
| ▸ | MMP2 | P08253 | 4/20 | 0.80 |
| ▸ | MMP9 | P14780 | 4/20 | 0.80 |
| ▸ | MMP8 | P22894 | 4/20 | 0.80 |
| ▸ | MMP13 | P45452 | 4/20 | 0.80 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943034 | 0.93 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6533676 | 0.93 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6506352 | 0.87 | HPSE (0.87) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6532513 | 0.87 | HPSE (0.87) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6506260 | 0.85 | MMP2 (0.93) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL481735 | 0.84 | NPC1 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL30933644 | 0.84 | MTOR (0.70) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL13942807 | 0.83 | NPC1 (0.70) | HPSEMMP2MMP9MMP8MMP13 | |
| Hydrochloric Acid SCHEMBL28051575 | 0.83 | NPC1 (0.70) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6529592 | 0.83 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |