Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 8/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | MMP2 | P08253 | 3/20 | 0.67 |
| ▸ | MMP9 | P14780 | 3/20 | 0.67 |
| ▸ | MMP8 | P22894 | 3/20 | 0.67 |
| ▸ | MMP13 | P45452 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | DDX3X | O00571 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533676 | 0.93 | HPSE (1.00) | HPSEKDM4ENPC1TP53MAPT | |
| SCHEMBL943034 | 0.93 | HPSE (1.00) | HPSEKDM4ENPC1TP53MAPT | |
| SCHEMBL6532513 | 0.87 | HPSE (0.87) | HPSEKDM4ENPC1TP53HPGD | |
| SCHEMBL6503052 | 0.87 | HPSE (0.87) | HPSEKDM4ENPC1TP53MAPT | |
| SCHEMBL7851030 | 0.85 | HPSE (0.79) | HPSEKDM4ENPC1TP53MAPT | |
| SCHEMBL6506260 | 0.85 | MMP2 (0.93) | HPSEKDM4ENPC1TP53MAPT | |
| SCHEMBL222131 | 0.84 | ALDH1A1 (1.00) | KDM4ENPC1TP53MAPTHPGD | |
| SCHEMBL30933632 | 0.84 | MTOR (0.70) | HPSENPC1TP53MAPTRAB9A | |
| Fluoride SCHEMBL31379729 | 0.83 | ALDH1A1 (0.96) | KDM4ENPC1TP53MAPTHPGD | |
| Methane SCHEMBL28366167 | 0.83 | ALDH1A1 (0.96) | KDM4ENPC1TP53MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |