Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496837 | 0.90 | ALOX5 (0.47) | ALOX5PTGS1PTGS2SLC6A3ALDH1A1 | |
| SCHEMBL6505363 | 0.85 | ALOX5 (0.66) | ALOX5PTGS1PTGS2 | |
| SCHEMBL6496415 | 0.84 | ALOX5 (0.47) | ALOX5PTGS1PTGS2SLC6A3ALDH1A1 | |
| SCHEMBL6505733 | 0.69 | PTGES (0.45) | ALOX5PTGS1PTGS2 | |
| SCHEMBL4148109 | 0.65 | ALOX5 (0.68) | ALOX5PTGS1PTGS2 | |
| SCHEMBL11304608 | 0.59 | FLT3 (0.69) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7479874 | 0.58 | ALOX5 (0.42) | ALOX5PTGS1ALDH1A1RAB9AKDM4E | |
| SCHEMBL28217093 | 0.58 | ALDH1A1 (0.51) | ALDH1A1RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL731363 | 0.58 | MAOB (0.71) | ALOX5ALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL31105656 | 0.58 | MAOB (0.71) | ALOX5ALDH1A1RAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |